America’s Poison Centers reported nearly 3,000 calls this year involving the weight loss drug semaglutide — a 15-fold increase since 2019, according to CNN.
Some of the people calling described symptoms related to accidental overdose. Those who needed to be hospitalized usually recovered once they received fluids and nausea meds.
Approved by the U.S. Food and Drug Administration in 2017, semaglutide is sold as Ozempic to treat diabetes and as Wegovy for weight loss.
Once celebrities started touting the drug’s weight loss effectiveness on social media last year, the public’s demand for semaglutide caused a shortage of the drug nationwide.
This shortage led the FDA to allow some pharmacies to make compounded versions of the drug, which often were different from the patented version, CNN reported. Many contained semaglutide salts and were not tested or approved as safe and effective.
Despite this, the knock-offs are in demand because they’re less expensive.
Although there is no way for them to know for sure if the poison center calls stemmed from the patented drug or the knock-offs, many state poison center directors told CNN they believed the compounded versions are to blame.
But how did people accidentally overdose?
Apparently, Ozempic and Wegovy arrive in safeguarded, prefilled pins. You dial to the correct dose then click to inject the medicine.
The compounded versions, however, often arrive in multidose vials and the medicine must be drawn into a syringe.
“This is where we see a lot of errors. They end up drawing too much,” said Dr. Joseph Lambson, director of the New Mexico Poison and Drug Information Center.
One of the calls Lambson’s team received was from a 37-year-old woman who accidentally gave herself 1 milliliter instead of 0.1 millilter — 10 times the recommended amount — as her first dose for weight loss, CNN reported.
With the name-brand versions, the dosage starts low and increases, so your body can get used to it.
That doesn’t mean they’re fool-proof, however. Julie Weber, director of the Missouri Poison Center, told CNN the center received a call from a woman who misunderstood how the pen worked.
“They did not know how to use it properly and dialed it up too (high) and took, like, the whole pen instead of just the dose that was supposed to happen,” she said. A pen is designed to last a month.
According to the center, signs of a semaglutide overdose include:
•Feeling lightheaded or dizzy
•Feeling shaky or jittery
•Sweating, chills and clamminess
•Irritability or impatience
•Headache
•Weakness
•Fatigue
•Nausea and/or vomiting
•Seizures
•Confusion
•Passing out
Whether you take the patented or the knock-off version, if you experience any of these symptoms, call your local poison control center.
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